Effect of ethanol extract of sida acuta burm f. leaves on egg albumin-induced inflammation.

2016-09-06T15-12-49Z
Source: Journal of Experimental and Integrative Medicine
Obioma Benedeth Eze, Okwesili Fred Nwodo, Victor Nwadiogo Ogugua, Parker Elijah Joshua.
ABSTRACT Objective: To evaluate the potential properties of ethanol extract of Sida acuta Burm F. leaves against inflammation. Methods: It was conducted using 25 adult wistar albino rats. They were divided into five groups of five rats each. Group1 administered 5 ml/kgb.wt. of normal saline (control group). Group 2, 3 and 4 administered 100, 200 and 400 mg/kgb.wt. of ethanol extract of Sida acuta leaves while group 5 were administered 200 mg/kgb.wt. of phenylbutazone (vehicle control). Paw oedema was induced using 0.1 ml of undiluted fresh albumin egg (philogistic agent) into the subplantar surface of the right hind paw of the rats. Superoxide dismutase activity, Catalase activity, Vitamine E concentration and Malondialdehyde level were assessed. Results: The extract at doses of 100, 200 and 400 mg/kgb.wt. and phenylbutazone 200 mg/kgb.wt. were administered intraperitoneally to respective groups of the rats. Control group received 5 ml/kgb.wt of normal saline. Doses of the extract 100, 200 and 400 mg/kg b.wt. significantly (p

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