Hyperleptinemia - an independent predictor of metabolic syndrome in the adult population in Kerala, India

2016-08-26T08-01-06Z
Source: International Journal of Research in Medical Sciences
Manju K. Sudharmadevi, Vijayalekshmi Lekshminarayan, Leena K. Balakumaran, Shenoy K. Trivikrama.
Background: Hyperleptinemia, associated with obesity which is a major risk factor for metabolic syndrome. Kerala has the highest prevalence of most of the cardio metabolic disorders and risk factors. So we analysed the ability of serum leptin level to predict the risk of developing metabolic syndrome among the adult population in Kerala, India. Methods: The study included 149 men and 155 women in the age group of 20-60years. Anthropometric measurements and Blood pressure were recorded. BMI and WHR were calculated. Fasting blood sample was used to measure serum leptin, insulin, lipid profile and glucose. HOMA-IR and HOMA-β were calculated. Baseline characterestics (means ± SEM) of men and women were examined by quartiles of serum leptin levels using ANOVA. The strength of association between leptin and components of metabolic syndrome was expressed as Odds Ratio (OR) using logistic regression analysis. p values


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