Effects of a diet containing Brazilian propolis on lipopolysaccharide-induced increases in plasma plasminogen activator inhibitor 1 (PAI-1) levels in mice

2016-08-17T17-26-20Z
Source: Journal of Intercultural Ethnopharmacology
Naoki Ohkura, Katsutaka Oishi, Fumiko Kihara-Negishi, Gen-ichi Atsumi, Tomoki Tatefuji.
Background: Brazilian propolis has many biological activities including the ability to help prevent thrombotic diseases, but this particular effect has not been proven. Plasma levels of plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, increase under inflammatory conditions such as infection, obesity and atherosclerosis and such elevated levels predispose individuals to a risk of developing thrombotic diseases. Aim: The present study aimed to determine the effects of a diet containing Brazilian propolis on LPS (lipopolysaccharide)-induced increases in plasma PAI-1 levels. Materials and Methods: Mice were fed with a diet containing 0.5% (w/w) Brazilian propolis for eight weeks. Thereafter, the mice were subcutaneously injected with saline containing 0.015 mg/kg of LPS and sacrificed four hours later. Results: Orally administered Brazilian propolis significantly suppressed the LPS-induced increase in PAI-1 antigen and its activity in mouse plasma. Conclusion: The present study indicated that Brazilian propolis contains natural products that can decrease thrombotic tendencies in mice.


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