Assessment of heart rate variability in participants with chronic obstructive pulmonary disease

2016-08-17T10-36-08Z
Source: National Journal of Physiology, Pharmacy and Pharmacology
Lalitha Surulichamy, Anandhalakshmi Swaminathan, Kanimozhi Sadasivam, Saravanan Ayyavoo.
Background: Chronic obstructive pulmonary disease (COPD) is one of the main causes of morbidity and mortality worldwide. COPD kills half a million people in India every year, more than those who die due to tuberculosis, malaria, or Acquired immune deficiency syndrome, and 30 million people suffer with COPD in India.[1] The hypoxemia due to COPD might be associated with autonomic dysfunction which could be evaluated with heart rate variability (HRV). Aims and Objective: To determine the HRV in patients with COPD and to compare with normal individuals. Materials and Methods: This cross-sectional study was carried out in 30 COPD patients attending the Department of Pulmonology, SRM Medical College Hospital and Research Centre and 30 age and sex-matched healthy individuals as a control group. A detailed history from the participants, such as weight and height, was obtained, and HRV parameters such as mean RR, mean HR, successive normal sinus RR intervals >50 ms (NN50), the percentage of successive normal sinus RR intervals >50 ms (pNN50), root mean square of successive heartbeat interval differences (rMSSDs), high frequency (HF), low frequency (LF), and LF/HF were estimated using physio-pac instrument. Results: HRV parameters such as rMSSD, NN50, PNN50, LF, HF, and LF/HF ratio show significant differences between the COPD and control (P

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