Potential Role of PAX5 in Breast Cancer: Relation to CD19

2016-07-24T23-20-37Z
Source: Journal of Investigational Biochemistry
Manal Basyouni Ahmed, Muneera Al-Sheeha, Maha Imam Ahmed, Enas Samir Nabih.
Background: PAX5 is a transcriptional factor that considered as one of the key molecules for regulation of many cancer associated genes. Objectives: The aim of this study was to examine status of PAX5 in human breast carcinoma through assessment its relation to CD19 expression. Patients and Methods: PAX5 and CD19 expression in breast tissue samples were measured by RT-PCR in 90 female breast specimens including 50 cases of invasive ductal carcinoma, 25 cases with fibroadenoma and 15 non-pathological breast tissue as control group. Results: The best cut-off values for the investigated markers were determined by ROC curve. PAX5 at 0.05 was 92.0% sensitivity and 92.5% specificity while CD19 at 0.62 was 94.0% sensitivity and 95.0% specificity. Moreover, positivity rates and mean levels for PAX5 and CD19 showed significant difference among the three investigated groups (p

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