N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances stability of internalized channels

Abstract

Studies in cultured hippocampal neurons and the COS-7 cell line demonstrate important roles for N-linked glycosylation of Kv1.2 channels in forward trafficking and protein degradation. Kv1.2 channels can contain complex N-linked glycans, which facilitate cell surface expression of the channels. Additionally, the protein stability of cell surface-expressed Kv1.2 channels is affected by glycosylation via differences in degradation of internalized channels. This study reveals the importance of N-linked complex glycosylation in boosting Kv1.2 channel density. Notably, sialic acids at the terminal sugar branches play an important role in dampening degradation of Kv1.2 internalized from the cell membrane to promote its stability.

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