Comparison of efficacy and outcome of intravenous immunoglobulin therapy versus plasmapheresis in patients with Gullian Barre syndrome

2016-05-30T02-37-55Z
Source: International Journal of Advances in Medicine
Archana Sonawale, Chetan Kalal.
Background: Acute inflammatory demyelinating polyneuropathy (AIDP) often described as Guillain-Barre syndrome (GBS) is an ascending neuropathy involving demyelination of peripheral nerves. Very few studies on GBS have been conducted in Indian scenario in recent years. Taking into account this background, we undertook this study to have better outlook to the spectrum of disease and outcome. The objective was to study the patients clinical profile, outcome of the disease and response to plasmapheresis (PP) versus intravenous immunoglobulin (IVIG) therapy in a case of GBS. Methods: This was a prospective observational study. In this study 34 consecutive patients who fulfilled the inclusion and exclusion criteria and who gave a written informed consent were recruited over a period of 2 years. A detailed history and physical examination was carried out in every patient. History of preceding illnesses and clinical symptoms were recorded. End points of the study were either death during hospital stay or discharge from the hospital, whichever was early. Results: Outcome in the present study was assessed using the modified Barthel index and modified Rankins scale. In IVIG group both MRS and MBS showed statistically favourable outcome, at the end of study (p


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