Effect of fampridine on axonal excitability in multiple sclerosis

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disorder of the human central nervous system and is the most common cause of non-traumatic chronic neurological disability among the young adult population (Hauser et al., 2006, Dutta et al., 2011). Eighty-five percent of new-onset MS is typically characterized by a relapsing-remitting (RRMS) course (Ransohoff et al., 2015). With the advent of novel disease modifying drugs that effectively expands the neurologist's therapeutic armamentarium, the frequency of clinical and/or radiological relapses are reduced.

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