Πέμπτη 7 Απριλίου 2016

Baseline Wall Thickness is Lower in Mucosa Healed Segments 1 Year After Infliximab in Pediatric Crohn's Disease Patients.

Objectives: We aimed to quantitatively investigate the therapeutic response to combined immunosuppression treatment by magnetic resonance enterography (MRE) in active luminal Crohn's disease in the pediatric population. Methods: Pediatric patients with moderate-to-severe luminal Crohn's disease who received scheduled infliximab and azathioprine were included in this preliminary study. Ileocolonoscopy and MRE were performed at baseline and at 1 year, and Simple Endoscopic Score for Crohn's Disease (SES-CD) and Magnetic Resonance Index of Activity (MaRIA) scores were calculated. The correlation between SES-CD and MaRIA scores were investigated with analysis per-person and per-segment. Results: A total 167 segments from 17 patients were evaluated by both ileocolonoscopy and MRE. SES-CD and MaRIA scores showed significant correlations on both per-person analysis ([rho] = 0.699, P

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