We thank the letter writers for their insightful comments on our article [1] and for highlighting the difficulty in creating a consistent spinal cord injury (SCI) in the rodent model. Over multiple studies [1–3], we have refined the surgical technique to be consistent and reproducible, with the senior author performing all the surgeries and utilizing computer assistance to ensure uniform impact to the spinal cords. All rats demonstrated consistent SCI after surgery upon examination using the Basso, Beattie, Bresnahan locomotor score.
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Τρίτη 21 Ιουνίου 2016
Response to letter to the editor regarding: “Local versus distal transplantation of human neural stem cells following chronic spinal cord injury” by Cheng et al
Letter to the editor regarding “Local versus distal transplantation of human neural stem cells following chronic spinal cord injury” by Cheng et al.
We read the recently published article "Local versus distal transplantation of human neural stem cells following chronic spinal cord injury" by Cheng et al. [1], with great interest. The article demonstrated "The transplantation of human neural stem cells (hNSCs) into the rat's chronically injured spinal cord led to significant functional recovery when injected distally but not locally to the site of chronic spinal cord injury (SCI)." Cheng et al. [1] evaluated functional recovery, post transplantation, using the 21-point Basso, Beattie, and Bresnahan locomotor score.
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Sagittal alignment changes and proximal junctional kyphosis in adolescent idiopathic scoliosis
Commentary On Basques BA, Long WD, 3rd, Golinvaux NS, Bohl DD, Samuel AM, Lukasiewicz AM, et al. Poor visualization limits diagnosis of proximal junctional kyphosis in adolescent idiopathic scoliosis. Spine J 2015. doi:10.1016/j.spinee.2015.10.040
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A postoperative risk scoring system?
Munch JL, Zusman NL, Lieberman EG, Stucke RS, Bell C, Philipp TC, et al. A scoring system to predict postoperative medical complications in high-risk patients undergoing elective thoracic and lumbar arthrodesis. Spine J 2016:16:694–9 (in this issue).
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Response to the letter to the editor regarding: “Circulatory dynamics of the cauda equina in lumbar canal stenosis using dynamic contrast-enhanced magnetic resonance imaging.” Spine J. 2015;15(10):2132–2141
We thank Dr Jeffrey S. Ross for their interest in our article and would like to respond to their criticisms of our work. We agree about our poor magnetic resonance imaging (MRI) technique and the need to improve it in the future. However, I think the visualization of intraradicular edema by MRI provides very useful help in the diagnosis of lumbar canal stenosis level before surgery. It is generally considered that the genesis of radiculopathy rests not only with mechanical compression but also with circulatory disturbance of the nerve root.
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Regarding “Circulatory dynamics of the cauda equina in lumbar canal stenosis using dynamic contrast-enhanced magnetic resonance imaging”
I read with interest the article by Kobayashi et al. in The Spine Journal October issue [1]. The occurrence of enhancement at the site of lumbar canal stenosis is an important one, and infrequently encountered in routine imaging of the lumbar spine, because contrast material is generally not given. When it does occur, it can be a source of confusion to the clinician and radiologist, who might ascribe a more ominous diagnosis of enhancing tumor or infection. The authors are to be commended for studying this topic.
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