Δευτέρα 7 Δεκεμβρίου 2020

Circular RNA circ_0004507 contributes to laryngeal cancer progression and cisplatin resistance by sponging miR‐873 to upregulate multidrug resistance 1 and multidrug resistance protein 1

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Abstract

Background

Circular RNAs (circRNAs) play critical roles in various types of cancer and chemosensitivity.

Methods

The expression levels of circ_0004507 and microRNA‐873 (miR‐873) were measured by quantitative real‐time polymerase chain reaction (qRT‐PCR). The interaction between circ_0004507 and miR‐873 was predicted by circinteractome and verified by dual‐luciferase reporter assay and RNA pull‐down assay. Xenograft tumor model was established to confirm the biological role of circ_0004507 in vivo.

Results

circ_0004507 was highly expressed and miR‐873 was lowly expressed in laryngeal cancer tissues. circ_0004507 knockdown or miR‐873 overexpression inhibited cell proliferation, migration and invasion, and increased apoptosis and cisplatin sensitivity in laryngeal cancer cells. miR‐873 was identified as a direct target of circ_0004507. circ_0004507 interference inhibited tumor growth and promoted cisplatin sensitivity by upregulating miR‐873 in vivo.

Conclusion

Knockdown of circ_0004507 inhibited laryngeal cancer progression and cisplatin resistance by sponging miR‐873, providing a potential target for laryngeal cancer therapy.

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