How does upper extremity Fugl-Meyer motor score relate to resting-state EEG in chronic stroke? A power spectral density analysis

Publication date: Available online 2 February 2019

Source: Clinical Neurophysiology

Author(s): M. Saes, C.G.M. Meskers, A. Daffertshofer, J.C. de Munck, G. Kwakkel, E.E.H. van Wegen, on behalf of the 4D-EEG consortium

Abstract

Objective

We investigated the potential added value of high-density resting-state EEG by addressing differences with healthy individuals and associations with Fugl-Meyer motor assessment of the upper extremity (FM-UE) scores in chronic stroke.

Methods

Twenty-one chronic stroke survivors with initial upper limb paresis and eleven matched controls were included. Group differences regarding resting-state EEG parameters (delta/alpha ratio (DAR) and pairwise-derived Brain Symmetry Index (BSI)) and associations with FM-UE were investigated, as well as lateralization of BSI and the value of different frequency bands.

Results

Chronic stroke survivors showed higher BSI compared to controls (p<.001), most pronounced in delta and theta frequency bands (p<.0001; p<.001). In the delta and theta band, BSI was significantly negatively associated with FM-UE (both p=.008) corrected for confounding factors. DAR showed no differences between groups nor association with FM-UE. Directional BSI showed increased power in the affected versus the unaffected hemisphere.

Conclusions

Asymmetry in spectral power between hemispheres was present in chronic stroke, most pronounced in low frequencies and related to upper extremity motor function deficit.

Significance

BSI is related to motor impairment and higher in chronic stroke patients compared to healthy controls, suggesting that BSI may be a marker of selective motor control.

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