Chronic pain is a unique pathophysiological state characterized by the formation of stable neurotransmitter, morphological, and behavioral patterns. Sleep has a facilitating influence on many pain syndromes by blocking signal conduction via the nociceptive pathways, the release of specific neurotransmitters, and the lack of conscious perception during this period. Restriction to the duration of sleep and impairment to its structure are accompanied by increased pain, while improvements in sleep in some cases allow pain to be decreased.
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