ERP indices of performance monitoring and feedback processing in psychosis: A meta-analysis

Publication date: Available online 10 August 2018

Source: International Journal of Psychophysiology

Author(s): Elizabeth A. Martin, Amanda McCleery, Melody M. Moore, Jonathan K. Wynn, Michael F. Green, William P. Horan

Abstract

Background

Although individuals with, or at risk for, psychotic disorders often show difficulties with performance monitoring and feedback processing, findings from studies using event-related potentials (ERPs) to index these processes are not consistent. This meta-analytic review focused on studies of two different indexes of performance monitoring, the early error-related negativity (ERN; n = 25) and the later error positivity (Pe; n = 17), and one index of feedback processing, the feedback negativity (FN; n = 6).

Methods

We evaluated whether individuals (1) with psychotic disorders, or (2) at heightened risk for these disorders differ from healthy controls in available studies of the ERN, Pe, and FN.

Results

There was a significant, large ERN reduction in those with psychosis (g = −0.96) compared to controls, and a significant, moderate ERN reduction in those at-risk (g = −0.48). In contrast, there were uniformly non-significant, small between-group differences for Pe and FN (gs ≤ |0.16|).

Conclusions

The results reveal a differential pattern of impairment in psychosis. Early performance monitoring (ERN) impairments are substantial among those with psychotic disorders in general and may be a useful vulnerability indicator for these disorders. However, later performance monitoring (Pe) and basic feedback processing (FN) appear to be relatively spared in psychosis.

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