Feasibility of Fully Automated Hypnosis, Analgesia, and Fluid Management Using 2 Independent Closed-Loop Systems During Major Vascular Surgery: A Pilot Study

Automated titration of intravenous anesthesia and analgesia using processed electroencephalography monitoring is no longer a novel concept. Closed-loop control of fluid administration to provide goal-directed fluid therapy has also been increasingly described. However, simultaneously combining 2 independent closed-loop systems together in patients undergoing major vascular surgery has not been previously detailed. The aim of this pilot study was to evaluate the clinical performance of fully automated hypnosis, analgesia, and fluid management using 2 independent closed-loop controllers in patients undergoing major vascular surgery before implementation within a larger study evaluating true patient outcomes. Accepted for publication March 30, 2018. Funding: Departmental. Conflicts of Interest: See Disclosures at the end of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). A. Joosten and V. Jame contributed equally and share first authorship. Institutional review board: This study was approved by our Institutional Review Board (IRB) of Erasme Hospital (808 Route de Lennik, 1070 Bruxelles, Belgium). E-mail: helene.francois@erasme.ulb.ac.be. Reprints will not be available from the authors. Address correspondence to Alexandre Joosten, MD, Hopital ERASME, 808, Rt de Lennik, 1070 Brussels, Belgium. Address e-mail to Alexandre.Joosten@erasme.ulb.ac.be; joosten-alexandre@hotmail.com. © 2018 International Anesthesia Research Society

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