Altered motor axonal excitability in patients with cervical spondylotic amyotrophy

Publication date: July 2018
Source:Clinical Neurophysiology, Volume 129, Issue 7
Author(s): Chaojun Zheng, Yu Zhu, Cong Nie, Feizhou Lu, Dongqing Zhu, Robert Weber, Jianyuan Jiang
ObjectiveTo investigate the changes in motor axonal excitability properties in cervical spondylotic amyotrophy (CSA).MethodsThreshold tracking was used to measure the median motor axons in 21 patients with CSA, 10 patients with cervical spondylotic radiculopathy (CSR) and 16 normal controls.ResultsCompared with normal controls, patients with distal-type CSA showed increased threshold electrotonus hyperpolarization (TEh [90–100]) and increased superexcitability on the symptomatic side (P < 0.05), which are suggestive of distal motor axonal hyperpolarization, presumably due to motor axonal regeneration. More importantly, compared with normal controls and CSR cases, both distal- and proximal-type CSA cases showed lower accommodation during depolarising currents (reduced S2 accommodation, decreased TEd [undershoot] and/or lower subexcitability) (P < 0.05), indicating that slow K⁺ conductance may be less active in motor axons in patients with CSA.ConclusionsThe present study demonstrated changes in motor axonal excitability in patients with CSA compared with both normal controls and patients with CSR.SignificanceLess expression of slow K⁺ conductance may confer greater instability in membrane potential in CSA, thereby presumably contributing to the increased vulnerability of motor axons in patients with CSA.



from Physiology via xlomafota13 on Inoreader https://ift.tt/2w9oBfj
via IFTTT