Nearly ten years ago, Tobin described the irony that evidence-based medicine (EBM) lacks a sound scientific basis.1 A sentinel paper concluded that most results of medical research were false,2 and now the same author, a well-lauded EBM proponent, argues that even if true, most clinical research is not useful3 and now concedes that EBM has been 'hijacked' by 'vested interests' including industry and researchers.4 The community expends vast resources on research, yet it has been estimated that there is an 85% 'waste in the production and reporting of research evidence'.5
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