High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults.

Purpose: Modulation of vascular function follows an exercise intensity-dependent pattern in young adults. This study aimed to investigate the potential intensity-dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults. Methods: Eleven healthy older adults (5 males/6 females, 66+/-1 years) completed 30 minutes of recumbent cycling at 50-55% (low-intensity) and 75-80% (high-intensity) of their age-predicted maximal heart rate on two separate study visits. Doppler ultrasound measures of brachial artery flow-mediated dilation (FMD) and reactive hyperemia (RH) were taken at baseline, ten minutes post-exercise, and one hour post-exercise. Additionally, cardiovascular hemodynamics and brachial shear rate were measured every five minutes during exercise. Results: Brachial artery FMD was enhanced ten minutes after high-intensity (4.8+/-0.2 to 9.1+/-0.3%, P0.05). Conclusion: Our data indicate that high-intensity exercise acutely enhances conduit artery function in healthy older adults. Additionally, an acute bout of exercise enhances resistance artery function independent of intensity. (C) 2017 American College of Sports Medicine

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