Δευτέρα 17 Ιουλίου 2017

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Recent studies have provided insights into the sources of endogenous replication stress, which can result in DNA damage, checkpoint activation and genome-wide replication fork slowing. The authors review established mechanisms involved in the replication stress response, and propose a new model that reconciles data gained from different cellular models.

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