SCOPE-mTL: a non-invasive tool for identifying and lateralizing mesial temporal lobe seizures prior to scalp EEG ictal onset

The first phase in epilepsy presurgical evaluation uses scalp EEG monitoring to record seizures, with the intent of lateralizing and localizing the seizure onset zone. While scalp EEG is non-invasive and cost-effective, several drawbacks frequently hamper interpretation of these recordings. First, scalp EEG recordings are prone to extracerebral artifacts. Myogenic artifacts at the start of a seizure can obscure cerebral activity, making it difficult to lateralize or localize seizure onsets. Second, scalp EEG has poor sensitivity for deep brain structures.

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