Low-grade intraductal carcinoma of the prostate: An idea whose time has not yet come

Abstract

Shah et al describe a prostatic intraductal proliferation morphologically intermediate between high-grade PIN (HGPIN) and intraductal carcinoma (IDCP) for which they use the term “atypical intraductal proliferation (AIP).¹ They compared the clinicopathological and immunohistochemical characteristics (ERG and PTEN expression) of AIP and IDCP in consecutive prostate biopsies and concluded based on this and previous findings² that AIP represents lower-grade morphological spectrum of IDCP associated with an intermediate risk of associated prostate cancer compared to HGPIN and IDCP. Finally, they propose expanding the morphological spectrum of IDCP to include AIP within the category of “low-grade IDCP” (LG-IDCP).adenocarcinoma could represent a morphological continuum with rather arbitrary cut-offs.

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