We present here a review of the use of the Morris water maze to identify impairments to the cognitive functions of the brain as part of the evaluation of the toxic actions of nanoparticles. Model experiments showed that individual variability in animals' behavior has significant influences on the results obtained in the water test. The need for preliminary selection of individuals as a measure to reduce such influences is grounded and the type of behavior displayed by the animal in the test to be used as the criterion for selection is discussed.
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