Sleep-related modifications of EEG connectivity in the sensory-motor networks in Huntington Disease: An eLORETA Study and Review of the Literature

Huntington's disease (HD) is a progressive hereditary neurodegenerative disorder caused by an abnormal expansion of a CAG triplet in the gene encoding the protein huntingtin on chromosome 4 (The Huntington's Disease Collaborative Research Group, 1993). HD is associated with severe clinical consequences such as progressive motor dysfunction, cognitive decline, and psychiatric disturbance (Walker, 2007). Sleep disturbances are a widespread problem in patients with HD (Nguyen et al., 2010; Morton, 2013).

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