The influence of statins on osseointegration: a systematic review of animal-model studies

Abstract

The increase in the use of immediately loaded dental implants and implant anchorage in low-density bone tissue has led to a need for accelerating and improving the osseointegration process. In some groups, such as osteoporosis patients, this need may be even greater. Previous investigations have demonstrated that osteoporosis can impair the process of osseointegration in an experimental model^1,2. In this context, several studies have reported strategies to enhance osseointegration, such as the use of growth factor and/or stem cells, hormone replacement, the development of nanosurfaces and nanotechnology, the use of new titanium alloys, surface chemistry and the use of drugs.

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