Apoptosis of T-Cell Subsets after Acute High-Intensity Interval Exercise

Introduction: High-intensity interval training (HIT) exercise has gained much interest in both performance and recreational sports. This study aims to compare the effect of HIT versus continuous (CONT) exercise with regard to changes of circulating T cells and progenitor cells. Methods: Subjects (n = 23) completed an HIT test and an isocaloric CONT test. Blood samples were collected before, immediately after, and 3 and 24 h postexercise for the assessment of low differentiated (CD3+CD28+CD57−), highly differentiated T cells (CD3+CD28−CD57+), regulatory T cells (Tregs) (CD4+CD25+CD127−), hematopoietic progenitor cells (CD45+CD34+), and endothelial progenitor cells (CD45−CD34+KDR+) by flow cytometry. The detection of apoptosis was performed by using labeling with annexin V. To analyze potential mechanisms affecting T cells, several hormones and metabolites were analyzed. Results: Both exercise tests induced an increase of catecholamines, cortisol, and thiobarbituric acid–reactive substances (P

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