Sarcopenia and Physical Function in Middle-Aged and Older Stroke Survivors

Publication date: Available online 13 August 2016
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Alice S. Ryan, Frederick M. Ivey, Monica C. Serra, Joseph Hartstein, Charlene E. Hafer-Macko
ObjectiveTo determine the prevalence of sarcopenia in stroke survivors using different methodologies and compared a subset of the stroke group to age, sex, and BMI-matched non-stroke control counterparts.DesignCohort StudySettingVeterans Affairs Medical Center and University HospitalParticipantsMild to moderately disabled chronic participants with stroke aged 40-84 yrs (n=190, 61% male, 57% African American, BMI: 29±1 kg/m², X±SEM)InterventionsNot applicableMain Outcome MeasuresDXA scans to assess appendicular lean mass (ALM). Rates of sarcopenia were determined using four established methods: 1) ALM/ht²; 2) European Working Group on Sarcopenia in Older Persons; 3) International Working Group on Sarcopenia; and 4) ALM/BMI.ResultsSarcopenia prevalence in our stroke cohort ranged between 14% and 18%. The stroke survivor subset (n=38) matched one-for-one with control counterparts for race, sex, age±4 years and BMI±2.5 units had higher prevalence rates compared to their non-stroke counterparts (13.2% vs. 5.3%, P<0.0001). ALM/ht² was related to six-minute walking speed (r=0.28, P<0.01) and VO2peak (l/min r=0.58, P<0.0001) for the stroke group.ConclusionsStroke survivors show an elevated prevalence of sarcopenia when considering age, sex, and race to non-stroke individuals.



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