EVALUATION OF THERAPEUTIC POTENTIAL OF AEGLE MARMELOS (BILVA) LEAVES IN METABOLIC SYNDROME

2016-07-22T05-35-06Z
Source: Indo American Journal of Pharmaceutical Research
Amit Vaibhav*, Prof. O.P. Singh.
Metabolic Syndrome is a cluster of disease highly prevalent in the sophisticated, modernized and western world. It received increased attention in the past few decades and is the burning problem of todays world. The metabolic syndrome has been shown to be a powerful risk factor responsible for coronary artery disease, renal failure, neuropathy etc. The conventional treatment option is only limited to managing hyperglycemia, dyslipidemia, hypertension but unable to prevent disease pathogenesis and complications. Long term side effect of artificial chemical drugs are another big problem, keeping these points in the account a pilot study has been framed to evaluate the therapeutic potential of Aegle marmelos (Bilva) leaves in Metabolic Syndrome. Aegle marmelos (Bilva) plant is vividly described in all ancient Ayurvedic texts known for its potent anti-diabetic, antioxidant, anti-inflammatory and anti-hyperlipidaemic activities. The main objective of the present work to evaluate the therapeutic potential of crude leaf powder of Aegle marmelos (Bilva). In this present study, total 30 previously diagnosed MS patients were randomly selected and divided into two groups having 15 patients in each group. In group I (n=15) patient have advised taking starch capsule 500 mg BD as a placebo and in Group II (n=15) crude leaf powder of Aegle marmelos (Bilva) 10 g BD has been given for 3 months with follow-up of 1 month. During the entire course of therapy, patients were advised to continue their ongoing conventional treatment along with the trial drug. The result showed a significant improvement in dyslipidemic state and hyperglycemic state of MS patient as compared to placebo group. The study can be concluded that the crude leaf powder of Aegle marmelos (Bilva) exhibit excellent hypolipidemic and hypoglycemic potential in MS patients, it can be used as natural, safe alternative to conventional management in the management of Metabolic Syndrome (MS).


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