Cardiorespiratory Response to Different Exercise Tests in Interstitial Lung Disease.

Introduction: The 6-minute stepper test (6MST) has been used as an alternative to the 6-minute walk test (6MWT) to assess exercise tolerance in patients with interstitial lung disease (ILD). Recent data suggest that the tests may involve different energy pathways and cardiorespiratory responses. We thus aimed to compare the cardiorespiratory responses of ILD patients during the 6MWT and the 6MST. Methods: Thirty-one patients with ILD were randomised to perform both tests in the order 6MST->6MWT (n=16) or 6MWT->6MST (n=15). Gas exchange, heart rate, and pulse O2 saturation (SpO2) were measured continuously, and dyspnoea, leg discomfort, and blood lactate concentration were assessed before and immediately after each test. Results: Oxygen uptake (VO2) was lower (p=0.002) and respiratory equivalent ratio for O2 (VE/VO2) and respiratory exchange ratios were higher (both p

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