Oxidative stress in childhood steroid sensitive nephrotic syndrome and its correlation with DNA damage

2016-06-06T04-55-43Z
Source: International Journal of Contemporary Pediatrics
Priyanka Reddy, Seema Pavaman Sindgikar, Rathika Damodar Shenoy, Vijaya Shenoy.
Background: Imbalance in oxidative state has been hypothesized as causative factor in renal injury. Oxidant stress can result in DNA damage which can be measured by comet assay. The aim of the study was to assess the oxidative stress and DNA damage in children with NS. Methods: Children of NS during first episode/relapse and remission were recruited. Blood malondialdehyde (MDA), reduced-glutathione (GSH) and superoxide dismutase (SOD) levels were done to assess oxidative state and compared with controls. DNA damage was assessed by comet assay. Percentage DNA in tail, tail length and olive tail moment (OTM) were calculated. Comparison of various groups was done and correlation determined by appropriate statistical tests. Results: Study group consisted of 38 children in each group. MDA levels were high in NS group compared to remission and controls with statistical significance (p


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