Brachytherapy Using Elastin-Like Polypeptides with 131 I Inhibit Tumor Growth in Rabbits with VX2 Liver Tumor

Abstract

Background

Brachytherapy is a targeted type of radiotherapy utilized in the treatment of cancers. Elastin-like polypeptides are a unique class of genetically engineered peptide polymers that have several attractive properties for brachytherapy.

Aims

To explore the feasibility and application of brachytherapy for VX2 liver tumor using elastin-like polypeptides with ¹³¹I so as to provide reliable experimental evidence for a new promising treatment of liver cancer.

Methods

Elastin-like polypeptide as carrier was labeled with ¹³¹I using the iodogen method. Ten eligible rabbits with VX2 liver tumor were randomly divided into the treatment group (n = 5) and control group (n = 5). The treatment group received brachytherapy using elastin-like polypeptide with ¹³¹I, and in the control group, elastin-like polypeptide was injected into the VX2 liver tumor as a control. Periodic biochemical and imaging surveillances were required to assess treatment efficacy.

Results

The stability of elastin-like polypeptide with ¹³¹I in vitro was maintained at over 96.8 % for 96 h. Biochemistry and imaging indicated brachytherapy using elastin-like polypeptide with ¹³¹I for liver tumor can improve liver function and inhibit tumor growth (P < 0.05).

Conclusions

Elastin-like polypeptide can be an ideal carrier of ¹³¹I and have high labeling efficiency, radiochemical purity and stability. Brachytherapy using elastin-like polypeptide with ¹³¹I for liver tumor is a useful therapy that possesses high antitumor efficacy advantages.

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