Prevalence of Peripheral Eosinophilia at Diagnosis in Children with Inflammatory Bowel Disease.

Background: Inflammatory bowel disease (IBD) encompasses two disorders of unknown etiology: Crohn's disease (CD) and ulcerative colitis (UC). There has been a continuous search for markers for disease activity. Eosinophils are granulocytic leukocytes that are implicated in the pathogenesis of IBD. Objectives: The aim of this study was to examine the prevalence and significance of peripheral eosinophilia (PE) at diagnosis in children with IBD Methods: A comprehensive chart review of all children with diagnosed with IBD between January 2006 - August 2014 was performed. Patients with PE at diagnosis were compared to those without in relation to disease clinical activity and disease course. Results: A total of 109 children (mean age 14.6+2.77, range 4.5-17.9 years, 55 boys) with IBD (68 CD and 41 with UC) who were followed for a mean duration of 2.82+1.89 (range 0.1-9.2 years) were identified. At diagnosis, 44 (40.4%) children had PE which was more prevalent in patients with UC compared to those with CD (61.3 vs 36.3%, P

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