Objectives: To compare effects of 10 weeks yoga therapy (YT) and standard medical care (SMC) on abdominal pain and quality of life (QoL) in children with abdominal pain related-functional gastrointestinal disorders (AP-FGIDs). Methods: Sixty-nine patients, aged 8-18 years, with AP-FGIDs, were randomized to SMC complemented with YT or SMC alone. YT is a mixture of yoga poses, meditation and relaxation exercises and was given once a week in group-sessions. SMC consisted of education, reassurance, dietary advice and fibers/mebeverine if necessary. Pain intensity (PIS; 0-5) and frequency (PFS; 0-4) were scored in a pain diary and QoL was measured with KIDSCREEN-27. Follow-up was twelve months. Treatment response was defined as >=50% reduction of weekly pain scores. Results: At 1 year follow-up, treatment response was accomplished in 58% of the YT group and 29% of the control group (p = 0.01), no significant differences for other timepoints were found. YT, and not SMC, resulted in a significant reduction of PIS (p
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