Evidence of a broad histamine footprint on the human exercise transcriptome

Abstract

Histamine is a primordial signaling molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell-surface receptors. In humans, aerobic exercise is followed by a post-exercise activation of histamine H₁ and H₂ receptors localized to the previously exercised muscle. This could trigger a broad range of cellular adaptations in response to exercise. Thus, we exploited RNA sequencing to explore the effects of H₁ and H₂ receptor blockade on the exercise transcriptome in human skeletal muscle tissue harvested from the vastus lateralis. We found that exercise exerts a profound influence on the human transcriptome, causing the differential expression of more than 3000 protein-coding genes. The influence of histamine blockade post-exercise was notable for 795 genes which were differentially expressed between the control and blockade condition, which represents > 25% of the number responding to exercise. The broad histamine footprint on the human exercise transcriptome crosses many cellular functions including inflammation, vascular function, metabolism, and cellular maintenance.

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