Cellular electrophysiological principles that modulate secretion from synovial fibroblasts

Abstract

Rheumatoid arthritis (RA) is a progressive disease that affects both pediatric and adult populations. The cellular basis for RA has been investigated extensively using animal models, human tissues and isolated cells in culture. However, many aspects of its etiology and molecular mechanisms remain unknown (McInnes & Schett, 2011). Some of the electrophysiological principles that regulate secretion of essential lubricants (hyaluronan and lubricin) and cytokines from synovial fibroblasts (FLS) have been identidied. Data sets describing the main types of ion channels that are expressed in human FLS preparations have begun to provide important new insights into the interplay among: (i) ion fluxes, (ii) Ca²⁺ release from the endoplasmic reticulum (ER) (iii) intercellular coupling and (iv) transient and longer duration changes in FLS membrane potential. Combination of this information, knowledge of similar patterns of responses in cells that regulate the immune system, and the availability of adult human synovial fibroblasts are likely to provide new pathophysiological insights.

This article is protected by copyright. All rights reserved

from Physiology via xlomafota13 on Inoreader http://ift.tt/1TVqj7z
via IFTTT