Limits of Evidence Based Medicine for rare diseases: The case of Budd-Chiari syndrome

Diffusion of the concepts of Evidence Based Medicine (EBM) as a rule for clinical field-practise has certainly had a positive and effective impact on the management of patients affected by different diseases. Moreover, EBM has long been a watershed between traditional medicine basically without rules, and a new approach to patients and diseases based only on evidence proven, so undeniably having an important social value. Through his own personal and deep thought, Pagliaro here outlines both the achievements and boundaries of EBM [1].

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