Investigation on hypoglycemic effects of ethanol extract of Alpinia nigra (Gaertn.) in animal model.

2016-03-24T13-22-11Z
Source: Journal of Intercultural Ethnopharmacology
Mohammad Shah Hafez Kabir, Mir Muhammad Nasir Uddin, S. M. Zahid Hosen.
Background: Our study aims at exploring the hypoglycemic effect, efficacy and possible mode of action of ethanol extract of Alpinia nigra (EEAN) as an antidiabetic agent in animal model. Methods: Oral glucose tolerance test (OGTT) was used to identify primary hypoglycemic effect in mice. Three tests (glucose absorption, sucrose absorption and disaccharidase activity) were carried out by gut-perfusion and six segments studies to assess carbohydrate absorption and glucose utilization. Results: In OGTT, at 400 mg/kg and 800 mg/kg dose of EEAN extract significantly improved oral glucose tolerance among normal mice at 60 min and 90 min with compared to control. both doses of extract significantly (P


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