Comparison of effects of rocuronium bromide vs. vecuronium bromide on hemodynamic parameters during anaesthesia for elective surgical procedures

2016-03-21T08-00-44Z
Source: International Journal of Basic & Clinical Pharmacology
Anjali P. Savargaonkar, Dipakkumar H. Ruparel, Ranjit S. Patil.
Background: Understanding haemodynamic effects of muscle relaxants may help us in selection of most appropriate muscle relaxant in a given case after considering preoperative cardiac status, preoperative medications, anaesthetic drugs to be used, nature of surgery and desirable intraoperative hemodynamics. Hemodynamic effects of rocuronium are not as clear as vecuronium. Present study was conducted to compare haemodynamic parameters during general anaesthesia for elective surgical procedures with vecuronium vs. rocuronium as muscle relaxant. Methods: Haemodynamic effects of vecuronium 0.15 mg/kg and 0.9 mg/kg of rocuronium was evaluated in patients (25 patients in each group) undergoing elective surgical procedures not lasting more than two hours. During this study period patients were evaluated for heart rate (HR), systolic BP (SBP), diastolic BP (DBP) and mean arterial pressure (MAP). Results: When both groups were compared, degree of fall in heart rate was more in vecuronium group (V group) compared to rocuronium group at all-time intervals after administration of drug. The fall in mean heart rate in V group was significant at two minutes after administration of muscle relaxant when compared to R group i.e.77.12±9.96 vs. 85.04±12.82 (p


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