4’-THIODNA: UNEXPECTED BEHAVIOUR

2016-02-29T03-14-14Z
Source: International Journal of Current Research and Review
Mohamed I. Elzagheid.
This viewpoint briefly discusses the impact of 4-thiosubstitution on oligonucleotides behaviour. The study in the reviewed articles has shown unexpected A-form formation, and unexpected RNA-like behaviour of the 4-thioDNA. This has been confirmed by the unexpected interaction of 4-thioDNA with Lividomycin A, a RNA major groove binder, and by resistance to cleavage by DNase I, which is a DNA-specific endonuclease. 4-ThioDNAwas also recognized by RNase V1 which is a RNA-specific endonuclease. These all findings will trigger the main focus of this viewpoint.


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