Πέμπτη 5 Ιουλίου 2018

LncPipe: A Nextflow-based pipeline for identification and analysis of long non-coding RNAs from RNA-Seq data

Publication date: Available online 6 July 2018

Source: Journal of Genetics and Genomics

Author(s): Qi Zhao, Yu Sun, Dawei Wang, Hongwan Zhang, Kai Yu, Jian Zheng, Zhixiang Zuo



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Identifying the relationship between oscillatory dynamics and event-related responses

Publication date: Available online 5 July 2018

Source: International Journal of Psychophysiology

Author(s): Julie M. Schneider, Mandy J. Maguire

Abstract

Event related potentials (ERPs) and time frequency analysis of the EEG can identify the temporally distinct coordination of groups of neurons across brain regions during sentence processing. Although there are strong arguments that ERP components and neural oscillations are driven by the same changes in the neural signal, others argue that the lack of clear associations between the two suggests oscillatory dynamics are more than just time frequency representations of ERP components, making it unclear how the two are related. The current study seeks to examine the neural activity underlying auditory sentence processing of both semantic and syntactic errors to clarify if ERP and time frequency analyses identify the same or unique neural responses. Thirty-nine adults completed an auditory semantic judgment task and a grammaticality judgment task. As expected, the semantic judgment task elicited a larger N400 and greater increase in theta power for semantic errors compared to correct sentences and the syntactic judgment task elicited a greater P600 and beta power decrease for both grammatical error types compared to syntactically correct sentences. Importantly, we identified a significant relationship between the N400 and P600 ERPs and theta and beta oscillatory dynamics during semantic and syntactic processing. These findings suggest that ERPs and neural oscillations measure similar neural processes; however, unaccounted for variance may indicate that neural oscillations provide additional information regarding fluctuations in power within a given frequency band. Future studies that vary semantic and syntactic complexity are necessary to understand the cognitive processes that are indexed by these oscillations.



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Selective intradural dorsal rhizotomy for persistent radicular leg pain: a contemporary series

Lumbar disc surgery for radicular leg pain is one of the most frequently performed spine procedures. In approximately 20% of patients poor outcome is achieved. The most complex cases have persistent leg pain without residual nerve root compression. Treatment for refractory cases is limited to medical pain management, spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS). For the latter two, fair to good results are obtained in only 50% of patients and costs and complication rates are high.

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Discretized Modeling of Motionless Printing Based on Retarded Bending Motion and Deposition Control of Electrically Driven Jet

3D Printing and Additive Manufacturing, Ahead of Print.


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Ultrasound-guided left lateral transversus abdominis plane block combined with rectus sheath block in peritoneal dialysis catheter placement

Abstract

This study assessed the utility of ultrasound-guided lateral transversus abdominis plane (TAP) block combined with rectus sheath (RS) block for peritoneal dialysis catheter placement surgery. Thirty consecutive patients with end-stage renal disease scheduled to have peritoneal dialysis catheter placement received a left lateral TAP block combined with RS block performed under ultrasound guidance. The TAP and RS blocks were, respectively, conducted with 15 ml of 0.5% ropivacaine and 10 ml of 0.5% ropivacaine. Pain intensity was evaluated by verbal rating scale during operation, and the degree of patient and surgeon satisfaction was qualified by a categorical scale. Twenty-nine patients received successful blocks without any other adjuvant anesthetic drugs. One patient required rescue analgesia with lidocaine infiltration. No complications related to regional anesthesia were noted. Ultrasound-guided left lateral TAP block combined with RS block can serve as the primary anesthetic modality for peritoneal dialysis catheter placement surgery.



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Regional Anesthesiology and Acute Pain Medicine in the Era of Value-Based Health Care

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Publication date: Available online 27 June 2018

Source: Anesthesiology Clinics

Author(s): Edward R. Mariano, Nabil M. Elkassabany



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Regional Anesthesia: What We Need to Know in the Era of Enhanced Recovery After Surgery Protocols and the Opioid Epidemic

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Publication date: Available online 15 June 2018

Source: Anesthesiology Clinics

Author(s): Lee A. Fleisher



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