Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism [Genetics]

Although "genomically" humanized animals are invaluable tools for generating human disease models as well as for biomedical research, their development has been mainly restricted to mice via established transgenic-based and embryonic stem cell-based technologies. Since rats are widely used for studying human disease and for drug efficacy and toxicity testing,...

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