2. The anticonvulsant effects of intravenous 5a-dihydroprogesterone on amygdala-kindled seizures in rats

5a-dihydroprogesterone (DHP), the first metabolite of progesterone and the precursor of allopregnanolone, has anticonvulsant properties. Past studies have reported the suppression of amygdala-kindled seizures by DHP administered via the subcutaneous route. We now demonstrate strong anticonvulsant effects of DHP administered intravenously (IV) via the jugular vein.

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