Event-related brain potentials elicited by high-speed cooling of the skin: a robust and non-painful method to assess the spinothalamic system in humans

Neuropathic pain is defined by the International Association for the Study of Pain as "pain arising as a direct consequence of a lesion or disease of the somatosensory system" (Loeser and Treede, 2008). This implies that the diagnostic work-up of neuropathic pain requires clinical tools to assess the function of the somatosensory system, including the function of the spinothalamic system. The most recent guidelines on neuropathic pain assessment state that the recording of laser-evoked brain potentials (LEPs) – i.e.

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