Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability [Genetics]

During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic cells prevent harmful R loops, we used human activation-induced cytidine deaminase (AID) to identify genes preventing...

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