Highly Concentrated Preterm Formula as an Alternative to Powdered Human Milk Fortifier: A Randomized, Controlled Trial.

Objective: To assess clinical feasibility and tolerance of concentrated preterm formula at 30 kcal/oz (CPF30) to fortify human milk to a caloric density of 24 kcal/oz, compared to conventional Powdered Human Milk Fortifier (PHMF). Study Design: Very low birth weight (VLBW) neonates were stratified by birth weight and randomized to receive human milk fortification using CPF30 or PHMF. Infants were monitored from first introduction of human milk fortification, until fortified feeds were well tolerated. Primary outcome was weight gain; secondary outcomes included other measures of feeding intolerance (residual gastric aspirates, feeds held, prokinetic therapy), sepsis, and death. The clinical and study personnel were blinded to the intervention. Results: No significant differences in weight gain or other measures of feeding tolerance were demonstrated between CPF30 and PHMF. Macronutrient intake was similar between both groups. There were fewer NPO days and a trend towards lower NEC incidence on CPF30 in the subgroup with a birth weight of more than 1000 gm. The amount of human milk consumed was significantly lower in the CPF30 group. Conclusion: Both fortifiers were similarly well tolerated. Fortification of human milk with CPF30 is a safe and feasible alternative to conventional PHMF. (C) 2017 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,

from Gastroenterology via xlomafota13 on Inoreader http://ift.tt/2tqQHNM
via IFTTT