When a needle is inserted into the stopper of a medication vial, small pieces of the stopper could be 'cored' inside the bore of the needle, consequently aspirated, and then injected into the body. Reported coring rates vary from 3.1% to 97%. This article reviews the literature surrounding this topic and covers: the rate of coring, its risk factors, and particle size, as well as prevention techniques to maximize safety during interventional procedures.
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